Proteasome biology and therapeutics in cardiac diseases
نویسندگان
چکیده
منابع مشابه
2 Proteasome inhibitors in experimental therapeutics of autoimmune diseases
Submitted 2 Proteasome inhibitors in experimental therapeutics of autoimmune diseases Submitted 28 Abstract Current treatment strategies for rheumatoid arthritis (RA) consisting of disease modifying antirheumatic drugs or biological agents are not always effective , hence driving the demand for new experimental therapeutics. The anti-proliferative capacity of proteasome inhibitors (PIs) has rec...
متن کاملProteasome inhibitors as experimental therapeutics of autoimmune diseases
Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying anti-rheumatic drugs or biological agents are not always effective, hence driving the demand for new experimental therapeutics. The antiproliferative capacity of proteasome inhibitors (PIs) has received considerable attention given the success of their first prototypical representative, bortezomib (BTZ), ...
متن کاملProteasome inhibitors as therapeutics.
The ubiquitin-proteasome pathway is a principle intracellular mechanism for controlled protein degradation and has recently emerged as an attractive target for anticancer therapies, because of the pleiotropic cell-cycle regulators and modulators of apoptosis that are controlled by proteasome function. In this chapter, we review the current state of the field of proteasome inhibitors and their p...
متن کاملRole of Epigenetics in Biology and Human Diseases
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurod...
متن کاملChemical biology: probes and therapeutics
In the Chemical Biology Minisymposium, cochaired by Alice Ting and Lisa Belmont, the first three talks focused on the development of novel probes for cell biology, while the last three presentations highlighted inhibitors of proteins previously believed to be " undruggable. " Daniel Hochbaum (Cohen lab, Harvard University) described an optical probe for imaging single action potentials using th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational Research
سال: 2019
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2018.09.003